Traditional methods of treatment
In most cases hamstring strain is treated conservatively and the principle mode of treatment follows the PRICE acronym (protection, rest, ice, compression, elevation). Unless the strain is a complete rupture, the body will initiate the injury-repair process and begin producing a functional scar to repair the damaged-tissue site. During this repair process it is important for the client to avoid activities that may further aggravate the site of tissue damage.

Most treatments aim to provide the optimal environment for the healing process to be most productive. Various physical-therapy methods, such as stretching, range-of-motion activities, and eventual strength training, are used to enhance the healing process. A physician may prescribe anti-inflammatory medication, although long-term use of anti-inflammatory medication is generally not advised for this condition because of potential detrimental effects.

If there is a third-degree strain or one that includes a tendon avulsion (with or without fracture), surgery may be indicated. Not all avulsions need to be treated surgically, so it is important to seek a second opinion about the benefits and drawbacks of surgical intervention.