Sepracor Inc. (Nasdaq: SEPR) today announced that its Board of Directors has approved the appointment of Robert F. Scumaci as Executive Vice President and Chief Financial Officer. Mr. Scumaci most recently served as Executive Vice President, Corporate Finance, Administration and Technical Operations at Sepracor. Mr. Scumaci will assume his new role on May 20, 2008, replacing David P. Southwell, who is resigning to pursue other interests but will remain a consultant to the company through the end of the year.

“I am very pleased to announce Bob’s appointment as our new Chief Financial Officer,” said Adrian Adams, President and Chief Executive Officer of Sepracor. “Bob brings with him a wealth of skills in finance, administration and general management. Over the last 13 years, Bob has had a strong record of leadership and accomplishments at Sepracor and has recruited, developed and managed fully integrated accounting, finance, information technologies, human resources and facility engineering departments. We are embarking on a very exciting growth phase for the Company, and Bob will play an integral role in planning and executing our core strategy against the expectations we set.”

Prior to serving as Executive Vice President, Corporate Finance, Administration and Technical Operations at Sepracor, Mr. Scumaci served as Senior Vice President, Finance and Administration and Treasurer and Vice President of Finance and Controller. Mr. Scumaci also spent seven years at Ares-Serono Group in various finance-related positions. Prior to Ares-Serono Group, Mr. Scumaci was employed at Revlon Health Care Group, and he began his career at Coopers and Lybrand.

About Sepracor

Sepracor Inc. is a research-based pharmaceutical company dedicated to treating and preventing human disease by discovering, developing and commercializing innovative pharmaceutical products that are directed toward serving large and growing markets and unmet medical needs. Sepracor’s drug development program has yielded a portfolio of pharmaceutical products and candidates with a focus on respiratory and central nervous system disorders. Sepracor’s corporate headquarters are located in Marlborough, Massachusetts.

For a copy of this release or any recent release,

visit Sepracor’s web site at www.sepracor.com.

Sepracor Inc.
David P. Southwell, 508-481-6700
Chief Financial Officer
or
Jonae R. Barnes, 508-481-6700
Sr. Vice President
Investor Relations

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